Ricerca USA: "Chemioterapia rende immuni alcuni tumori"
, 5 agosto 2012 - Una scoperta inattesa, e scioccante sotto certi aspetti, scuote gli ambienti scientifici impegnati nella
lotta al cancro
, usata da decenni per combattere i
, in realtà può stimolare, nelle cellule sane circostanti, la secrezione di una
proteina che sostiene la crescita
‘immune’ il cancro
a ulteriori trattamenti
Chemotherapy can backfire by 'encouraging cancer growth'
...Scientists now believe one reason why could be the effect the treatment has on healthy connective tissue cells called fibroblasts.
Scientists found DNA-damaging cancer drugs cause fibroblasts to pump out growth molecules that encourages prostate tumours to grow.
They measured high levels of one protein molecule WNT16B that helped cancer cells to grow, invade surrounding tissue, and resist treatment.Working in the laboratory,
scientists observed an up to 30-fold increase in WNT production in response to chemotherapy
Healthy cells around tumours 'help fuel chemotherapy resistance'
...Commenting on the finding, Professor Fran Balkwill, a Cancer Research UK expert on the microenvironment, said that this finding ties in with other research that has shown that "cancer treatments don't just affect cancer cells, but can also target cells in and around tumours". This effect can sometimes be a positive one, Professor Balkwill said, as is the case when chemotherapy stimulates healthy immune cells to attack tumours nearby...
Pubblicato il 6/8/2012 alle 10.48 nella rubrica Agenzie di Stampa.